Artículos de revistas
Evaluation of in vivo pathogenicity of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis with different enzymatic profiles in a murine model of disseminated candidiasis
Fecha
2014-02Autor
Treviño Rangel, Rogelio
Rodríguez Sánchez, Iram Pablo
Elizando Zertuche
Martínez Fierro, Margarita de la Luz
Garza Veloz, Idalia
Romero Diaz, Viktor
González, Jose
González, Gloria
Institución
Resumen
Six isolates of the Candida parapsilosis complex with different enzymatic profiles were used to induce systemic infection in immunocompetent BALB/c mice. Fungal tissue burden was determined on days 2, 5, 10, and 15 post challenge. The highest fungal load irrespective of post-infection day was detected in the kidney, followed by the spleen, lung,andliver,withatendencyforthefungalburdentodecreasebyday15inallgroups. Significant differences among the strains were not detected, suggesting that the three species of the “psilosis” group possess a similar pathogenic potential in disseminated candidiasis regardless of their enzymatic profiles