dc.contributorhttps://orcid.org/0000-0002-3403-9849
dc.creatorRamírez Sandova, Roxana
dc.creatorLuévano Rodríguez, Nayeli
dc.creatorRodríguez Rodríguez, Mayra
dc.creatorPérez Pérez, María Elena
dc.creatorSaldívar Elias, Sergio
dc.creatorGurrola Carlos, Reinaldo
dc.creatorAvalos Díaz, Esperanza del Refugio
dc.creatorBollain y Goytia, Juan José
dc.creatorHerrera Esparza, Rafael
dc.date.accessioned2020-12-06T19:25:04Z
dc.date.available2020-12-06T19:25:04Z
dc.date.created2020-12-06T19:25:04Z
dc.date.issued2015
dc.identifier23148861
dc.identifier23147156
dc.identifierhttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2182
dc.identifierhttps://doi.org/10.48779/bdbd-sd53
dc.description.abstractAutoimmune nephritis triggered by metallic ions was assessed in a Long-Evans rat model. The parameters evaluated included antinuclear autoantibody production, kidney damage mediated by immune complexes detected by immunofluorescence, and renal function tested by retention of nitrogen waste products and proteinuria. To accomplish our goal, the animals were treated with the following ionic metals: HgCl2, CuSO4, AgNO3, and Pb(NO3)2. A group without ionic metals was used as the control. The results of the present investigation demonstrated that metallic ions triggered antinuclear antibody production in 60% of animals, some of them with anti-DNA specificity. Furthermore, all animals treated with heavy metals developed toxic glomerulonephritis with immune complex deposition along the mesangium and membranes. These phenomena were accompanied by proteinuria and increased concentrations of urea. Based on these results, we conclude that metallic ions may induce experimental autoimmune nephritis.
dc.languageeng
dc.publisherHindawi
dc.relationgeneralPublic
dc.relationhttps://www.hindawi.com/journals/jir/2015/269610/
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/3.0/us/
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América
dc.sourceJournal of Immunology Research Vol. 2015, pp. 1-12
dc.titleAn Animal Model Using Metallic Ions to Produce Autoimmune Nephritis
dc.typeinfo:eu-repo/semantics/article


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