Ítem publicado en memoria de congreso/Conference Paper
Exploration of a novel mechanism of cardiac troponin release: in silico evidence of non-classical secretion
Fecha
2021-05-04Registro en:
Gonzalez-Rayas, J. M., Hernandez-Hernandez, J. A., Lopez-Sanchez, R. D. C., Rayas-Gomez, A. L., Gonzalez-Yanez, J. M. & Jerjes-Sanchez, C. (2021, May 4-5). Exploration of a novel mechanism of cardiac troponin release: in silico evidence of non-classical secretion [Poster presentation]. PDB50: A Special Symposium Celebrating the 50th Anniversary of the Protein Data Bank.
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Autor
González Rayas, José Manuel
Hernandez Hernandez, Jose Ascención
Lopez Sanchez, Rosa del Carmen
Rayas Gomez, Ana Lilia
Gonzalez Yanez, Jose Manuel
Jerjes Sanchez, Carlos
Institución
Resumen
Cardiac troponin is one of the most important biomarkers in cardiology. Traditionally, it has represented a biochemical sign of necrosis, a characteristic of acute myocardial infarction (AMI). However, with the arrival of high-sensitivity detection assays, cardiac troponin is now detected in healthy patients and in a number of uncommon scenarios unrelated to AMI (such as strenuous exercise, rapid atrial pacing and COVID-19). This suggests that troponin could be released as a consequence of alternative processes other than the well-stablished necrotic cell death.