Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins

dc.creatorGabriel Amador Aguirre
dc.creatorIrene Martín Del Estal
dc.creatorMaría Inmaculada Castilla de Cortázar Larrea
dc.creatorJosé Luis González Guerra
dc.date.accessioned2018-10-18T21:21:56Z
dc.date.accessioned2022-10-13T18:37:10Z
dc.date.available2018-10-18T21:21:56Z
dc.date.available2022-10-13T18:37:10Z
dc.date.created2018-10-18T21:21:56Z
dc.identifier19326203
dc.identifier10.1371/journal.pone.0181760
dc.identifierhttp://hdl.handle.net/11285/630439
dc.identifier12
dc.identifier8
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4196576
dc.publisherPublic Library of Science
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85027372642&doi=10.1371%2fjournal.pone.0181760&partnerID=40&md5=5030cb63c417b116697834e1c40f4ede
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightshttp://creativecommons.org/licenses/by/4.0
dc.sourcePLoS ONE
dc.subjectangiotensin II
dc.subjectcalcium
dc.subjectconnective tissue growth factor
dc.subjectcontractile protein
dc.subjectprotein Grem1
dc.subjectscleroprotein
dc.subjectsomatomedin B
dc.subjectsomatomedin B receptor
dc.subjectsomatomedin binding protein 1
dc.subjectsomatomedin binding protein 2
dc.subjectsomatomedin binding protein 3
dc.subjectsomatomedin binding protein 4
dc.subjectsomatomedin binding protein 5
dc.subjectsomatomedin binding protein 6
dc.subjectsomatomedin C
dc.subjectsomatomedin C receptor
dc.subjectunclassified drug
dc.subjectangiotensin II
dc.subjectbradykinin
dc.subjectsomatomedin C
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcalcium homeostasis
dc.subjectcontrolled study
dc.subjectcoronary artery blood flow
dc.subjectCtgf gene
dc.subjectextracellular matrix
dc.subjectgene
dc.subjectgene expression
dc.subjectGrem1 gene
dc.subjectheart muscle contractility
dc.subjectheart muscle fibrosis
dc.subjectheart weight
dc.subjecthistology
dc.subjectIgf1 gene
dc.subjectIgf1r gene
dc.subjectIgf2 gene
dc.subjectIgf2r gene
dc.subjectIgfbp1 gene
dc.subjectIgfbp2 gene
dc.subjectIgfbp3 gene
dc.subjectIgfbp4 gene
dc.subjectIgfbp5 gene
dc.subjectIgfbp6 gene
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectprotein blood level
dc.subjectreal time polymerase chain reaction
dc.subjectregulatory mechanism
dc.subjectreperfusion injury
dc.subjectanimal
dc.subjectbody weight
dc.subjectcardiac muscle
dc.subjectdeficiency
dc.subjectdrug effects
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjectheart contraction
dc.subjecthemodynamics
dc.subjectmetabolism
dc.subjectorgan size
dc.subjectpathology
dc.subjectperfusion
dc.subjecttransgenic mouse
dc.subjectvasoconstriction
dc.subjectvasodilatation
dc.subjectAngiotensin II
dc.subjectAnimals
dc.subjectBody Weight
dc.subjectBradykinin
dc.subjectExtracellular Matrix
dc.subjectGene Expression Regulation
dc.subjectHemodynamics
dc.subjectInsulin-Like Growth Factor I
dc.subjectMice, Transgenic
dc.subjectMyocardial Contraction
dc.subjectMyocardium
dc.subjectOrgan Size
dc.subjectPerfusion
dc.subjectReal-Time Polymerase Chain Reaction
dc.subjectVasoconstriction
dc.subjectVasodilation
dc.titlePartial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins
dc.typeArtículo


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