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Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice

Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice

dc.creatorMARTINEZ DOMINGUEZ, ANABELLA; 366002
dc.creatorCONTRERAS YANEZ, IRAZU; 176001
dc.creatorESTRADA GUADARRAMA, JOSE ANTONIO; 103917
dc.creatorMARTINEZ DOMINGUEZ, ANABELLA
dc.creatorCONTRERAS YANEZ, IRAZU
dc.creatorESTRADA GUADARRAMA, JOSE ANTONIO
dc.date2019-01-17T23:41:18Z
dc.date2019-01-17T23:41:18Z
dc.date2017
dc.date.accessioned2022-10-12T23:28:21Z
dc.date.available2022-10-12T23:28:21Z
dc.identifierhttp://www.redalyc.org/articulo.oa?id=41654732008
dc.identifierhttp://hdl.handle.net/20.500.11799/96909
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4149663
dc.descriptionOxidative stress (OS) is considered a risk factor for neurodegenerative disorders. Iron concentrations have been related to OS; however, the effect of iron deficiency (ID) on the induction of OS in the central nervous system (CNS) is unknown. A murine model of chronic diet-induced ID using 2 month-old male BALB/c mice (6 specimen), was used to determine its role in OS induction. Lipid peroxidation was determined by measuring thiobarbituric acid-reactive species (TBARS) in the CNS, using the spleen for comparison. A decrease of peroxidation products in the CNS of the ID group (ID CNS), compared to controls fed on a regular diet, was found. The spleen showed a significant increase of lipid peroxidation in the ID group. Our results suggest that chronic ID may have differential effects on OS in the CNS and peripheral tissues. A decreased amount of reactive oxygen species in the basal state may be related to alterations on normal CNS metabolism and functions under chronic ID.
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversidad de Guanajuato
dc.relationhttp://www.redalyc.org/revista.oa?id=416
dc.rightsActa Universitaria
dc.rightsopenAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceActa Universitaria (México) Num.6 Vol.27
dc.subjectMultidisciplinarias (Ciencias Sociales)
dc.subjectOxidative stress
dc.subjectlipid peroxidation
dc.subjectiron deficiency
dc.subjectcentral nervous system
dc.subjectspleen
dc.subjectMultidisciplinarias (Ciencias Sociales)
dc.subjectOxidative stress
dc.subjectlipid peroxidation
dc.subjectiron deficiency
dc.subjectcentral nervous system
dc.subjectspleen
dc.subjectCIENCIAS SOCIALES
dc.titleOxidative damage in lipids in the central nervous system and spleen in iron-deficient mice
dc.titleOxidative damage in lipids in the central nervous system and spleen in iron-deficient mice
dc.typeArtículo
dc.typeArtículo
dc.typearticle


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