info:eu-repo/semantics/article
Antigiardial activity of Cupania dentata Bark and its constituents
Autor
LUIS IGNACIO HERNANDEZ CHAVEZ
LUIS WILIUNFO TORRES TAPIA
PAULINO SIMA POLANCO
ROBERTO MANUEL CEDILLO RIVERA
ROSA ESTHER MOO PUC
SERGIO RUBEN PERAZA SANCHEZ
Institución
Resumen
The MeOH extract of Cupania dentata bark (Sapindaceae) as well as its hexane, CH 2Cl 2, EtOAc, and BuOH fractions showed high activity against Giardia lamblia trophozoites (IC 50 = 2.12-9.52 μg/mL). The phytochemical study of fractions resulted in the isolation of taraxerone (1), taraxerol (2), scopoletin (3), and two mixtures of steroidal compounds. Taraxerone was the metabolite with the highest giardicidal activity (IC 50 = 11.33 μg/mL).
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