Arsenic contamination has become a global issue due to ever-increasing contamination of groundwater, soil, and crops in many regions of the world. The use of groundwater with high arsenic (As) content in agricultural irrigation is a regular practice, which results in the accumulation of As in soils to levels that can alter soil physicochemical properties, decrease fertility, and reduce crop yield. Plants absorb many elements from soil and irrigation water. Some of these elements have a biological function but others, such as As, can be toxic to the plants. The presence of As in plants poses a risk due to the possible bioaccumulation of this metalloid through the food chain. Edible fruits like melon and watermelon are mainly grown in warm and arid or semi-arid locations. These crops have a high production and commercialization worldwide. The mechanisms for uptake, biotransformation, and bioaccumulation of As vary substantially between plant species and genotypes.