info:eu-repo/semantics/article
Simple approach for ranking structure determining residues
Autor
OSCAR DANIEL LUNA MARTINEZ
ABRAHAM MARCELINO VIDAL LIMON
MIRYAM IVETTE VILLALBA VELAZQUEZ
RAMON GARDUÑO JUAREZ
Vladimir Uversky
BALTAZAR BECERRIL LUJAN
Institución
Resumen
"Mutating residues has been a common task in order to study structural properties of the protein of interest. Here, we propose and validate a simple method that allows the identification of structural determinants; i.e., residues essential for preservation of the stability of global structure, regardless of the protein topology. This method evaluates all of the residues in a 3D structure of a given globular protein by ranking them according to their connectivity and movement restrictions without topology constraints. Our results matched up with sequence-based predictors that look up for intrinsically disordered segments, suggesting that protein disorder can also be described with the proposed methodology."
Materias
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