Tesis
Perfil metabólico de ratos adultos submetidos à restrição protéica na vida intrauterina e superalimentados durante a lactação
Fecha
2012-06-29Registro en:
COUTINHO, Grazielle Vitória Ponti. Perfil metabólico de ratos adultos submetidos à restrição protéica na vida intrauterina e superalimentados durante a lactação. 2012. 50 f. Dissertação (Mestrado em Biociências) - Universidade Federal de Mato Grosso, Faculdade de Nutrição, Cuiabá, 2012.
Autor
Martins, Maria Salete
Silva, Maria Helena Gaíva Gomes da
http://lattes.cnpq.br/3174964298120701
http://lattes.cnpq.br/8756059695102726
Martins, Maria Salete
102.452.944-49
http://lattes.cnpq.br/8756059695102726
Ferreira, Marciane Milanski
523.077.431-20
http://lattes.cnpq.br/6364009144655593
102.452.944-49
229.585.331-15
Reis, Marise Auxiliadora de Barros
025.079.108-01
http://lattes.cnpq.br/0243246676385123
Institución
Resumen
We investigated whether overfeeding during lactation following intrauterine protein
restriction would cause adult-onset obesity and metabolic disorders. After birth, litters
from dams fed with control (17% protein) and low protein (6% protein) diets were
adjusted to a size of four (CO and LO groups, respectively) or eight (CC and LC
groups, respectively) pups. All of the offspring were fed a diet containing 12% protein
from the time of weaning until they were 90 d old. Compared to the CC and LC groups,
the CO and LO groups had higher relative and absolute food intake, oxygen
consumption and carbon dioxide production; lower brown adipose tissue weight and
lipid content; but greater weight gain and white adipose tissues weight and lipid content.
Compared to the CO and CC rats, the LC and LO rats exhibited higher relative food
intake, brown adipose tissue weight and lipid content, reduced oxygen consumption,
carbon dioxide production and spontaneous activity, but unaltered white adipose tissue
weight and lipid content. Fasting serum glucose was similar between the groups. The
area under the glucose curve was higher in the LO and CO rats than in the LC and CC
rats. Basal insulinemia and homeostasis model assessment of insulin resistance
(HOMA-IR) were lower in the LO group than in the other groups. The total area under
the insulin curve for the LO rats was similar to the CC rats, and both were lower than
the CO and LC rats. Kitt was higher in the LO, LC and CO groups than in the CC group.
Thus, overfeeding during lactation increased visceral fat and, body mass, and it resulted
in glucose intolerance by impairing pancreatic function or insulin resistance.