Tesis
Fendas Orofaciais : estudo farmacoepidemiológico e o papel do ácido fólico
Fecha
2011-09-21Registro en:
FIGUEIREDO, Rita de Cássia Feguri. Fendas orofaciais: estudo Farmacoepidemiológico e o papel do ácido fólico. 2011. 131 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Mato Grosso, Faculdade de Medicina, Cuiabá, 2011.
Autor
Damazo, Amílcar Sabino
http://lattes.cnpq.br/3708368867452889
Damazo, Amílcar Sabino
165.559.138-00
http://lattes.cnpq.br/3708368867452889
Mesquita Júnior, Fernando de
452.664.731-04
http://lattes.cnpq.br/0443232085031155
165.559.138-00
Espósito, Mário Pinheiro
710.612.077-49
http://lattes.cnpq.br/9034073494906462
Institución
Resumen
The use of folate in preventing birth defects including OFCs (orofacial
clefts) is a path that for many decades until the present day, by several researchers, in
seeking to correlate the possible relationships between exposure and genetic susceptibility to environmental variables influencing or determining directly or indirectly the development of malformations such as OFC, discussing experimental and epidemiological
evidence for a possible role of folate in prevention. Objectives. Evaluate data collected
through entrevistaem women of reproductive age with folate supplementation and the
possible influence of diet as a factor preventing OFCs and importance of these and other
environmental variables in the development of this malformation, checking the possible
associations involved in homocysteine metabolism providing the potential for birth defects. Methods. We used an observational cross-sectional study if the primary control.Were collected from mothers of patients with OFCs composed of individuals of both
sexes treated at the Hospital Universitário Júlio Müller (HUJM) and the Hospital Geral
Universitario (HGU) in Cuiabá - MT, information of the mothers during the regular period,
pregnancy and pre pregnancy through a standardized interview, a total sample of 61 patients to identify socio-demographic, epidemiological, health care in which they interviewed experienced at different times of life when they sought a facility located within the
state of MT. Results. There was a low folate intake by mothers, especially in the affected
group (p<0,05). The orientation and prevention with folate supplementation was very poor in the whole sample, being non-existent in both groups of reproductive age, and significantly lower in the case group compared with the control in the peri-conception, that is,
three months before of gestation and the first trimester (p<0.05). There was also a failure of family planning in both groups. The 2D US (twodimensional ultrasound) showed a low sensitivity of prenatal diagnosis of OFCs during
pregnancy, birth and the examination showed low efficacy in the diagnosis
of isolated cleft palate. Conclusions. Through epidemiological studies conducted in
this thesis, we observed limited family planning, a diet low in folate by womeninterviewed,
and a deficiency of guidance and prevention of congenital anomalies like OFC with the
use of folate in women reproductive period and peri-conception. The diagnosys of
OFCs also seemed very poor, both during pregnancy with the use of 2D US, as at birth. Thus, it was evident the need to improve prevention and diagnosis
of OFCs with better qualification of the professionals involved and health awareness in
the community in general.