Tesis
Análise do perfil lipídico em pacientes com malária causada pelo Plasmodium vivax antes e após tratamento antimalárico
Fecha
2015-04-30Registro en:
MESQUITA, Teresinha Célia de. Análise do perfil lipídico em pacientes com malária causada pelo Plasmodium vivax antes e após tratamento antimalárico. 2015. 90 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Mato Grosso, Faculdade de Medicina, Cuiabá, 2015.
Autor
Fontes, Cor Jesus Fernandes
http://lattes.cnpq.br/5971254060419331
Fontes, Cor Jesus Fernandes
199.869.476-34
http://lattes.cnpq.br/5971254060419331
Santos, Fabrício Rios
891.650.555-00
http://lattes.cnpq.br/6822470099378179
199.869.476-34
Ferreira, Marcelo Simão
288.164.716-20
http://lattes.cnpq.br/4425673254987941
Institución
Resumen
Although serum lipids are known to be altered in Plasmodium falciparum-induced
malaria, little is known about such changes due to Plasmodium vivax infection. This study
assessed serum concentrations of triglycerides, total cholesterol, low-density lipoprotein
(LDL), and high-density lipoprotein (HDL) in 164 patients in the acute phase of malaria
caused by P. vivax and characterized these changes in the convalescent phase after treatment
with chloroquine and primaquine. Compared to reference values, serum total cholesterol,
LDL, and HDL levels were lower and triglyceride levels were higher in the acute phase.
Moreover, the parasite density was negatively correlated with LDL (r=-0,189; p=0.027) and
HDL (r=-0,256 ; p=0.001) serum levels. Eighty patients returned for clinical and laboratory
revaluation 7–12 days after treatment initiation. All patients showed parasite clearance and the
absence of symptoms during the convalescent phase. Analysis of the serum lipids of these 80
patients showed significant increases in the serum levels of total cholesterol (p<0.0001), LDL
(p<0.0001), and HDL (p<0.0001) as well as a significant reduction in triglycerides (p=0.004),
indicating a trend towards a return to normal levels. This transient change in the lipid profile
between the acute and convalescent phases of P. vivax infection may be useful for assessing
the therapeutic response of infections to antimalarials.