Polimorfismo -174 G/C del gen promotor de interleuquina 6 en mujeres con diabetes mellitus tipo 1

dc.creatorPÉREZ-BRAVO,FRANCISCO
dc.creatorSOTO M,FRANCISCA
dc.creatorLÓPEZ A,PATRICIA
dc.creatorEYZAGUIRRE C,FRANCISCA
dc.creatorCODNER,ETHEL
dc.date2011-02-01
dc.date.accessioned2017-03-07T16:37:24Z
dc.date.available2017-03-07T16:37:24Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000200003
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/404736
dc.descriptionBackground: A polymorphism located in the promoter region (-174 G I C) of interleukin 6 (IL-6) has been linked to early onset of type 1 diabetes (T1D) and increased body mass index (BMI). Aim: To evaluate the possible association of this -IL-6 gene 174 GIC polymorphism with T1D, BMI and metabolic control in T1D patients in a case-control study. Patients and Methods:-174 G I C polymorphisms were analyzed by polymerase chain reaction and restriction fragment length polymorphism in 145 women with T1D and 103 healthy controls. BMI and BMI-Z-scores were tabulated and metabolic control was recorded. Results: There was a higher frequency for the C allele in T1D patients compared with the control group (21% versus 14.1%, p = 0.047). No significant differences in genotype frequencies for the -174 GIC polymorphism of IL-6 gene between patients with T1D and controls, were observed. There were no significant associations with T1D and BMI. Conclusions: A higher frequency of C allele in women with T1D was the only finding in this series, suggesting that the polymorphic variant is not related to weight gain in these patients.
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dc.languagees
dc.publisherSociedad Médica de Santiago
dc.sourceRevista médica de Chile v.139 n.2 2011
dc.subjectBody mass index
dc.subjectDiabetes mellitus, type 1
dc.subjectInterleukin-6
dc.titlePolimorfismo -174 G/C del gen promotor de interleuquina 6 en mujeres con diabetes mellitus tipo 1
dc.typeArtículos de revistas


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