| dc.creator | BRAVO,FELIPE | |
| dc.creator | LOBOS,CLAUDIO | |
| dc.creator | VENEGAS,KARINA | |
| dc.creator | BENITES,JULIO | |
| dc.date | 2010-12-01 | |
| dc.date.accessioned | 2017-03-07T16:35:06Z | |
| dc.date.available | 2017-03-07T16:35:06Z | |
| dc.identifier | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000400009 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/404095 | |
| dc.description | Four benzodiazepines flunitrazepam, nitrazepam, clonazepam, and alprazolam, have been analyzed from biological matrices by dual column gas chromatography using a nitrogen-phosphorus detector (NPD) and a micro-electron capture detector (m-ECD). The recoveries of the four benzodiazepines spiked into human whole blood and plasma were 88.8 - 97.9 and 90.7 - 97.5%, respectively. The regression equations for the four benzodiazepines showed excellent linearity. The detection limits (LODs) were 0.14 - 0.95 ng/mL for whole blood and 0.13 - 0.93 ng/mL for plasma. The method is simple and sensitive for the determination of benzodiazepines in human whole blood and plasma, and may be useful in forensic science practice. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad Chilena de Química | |
| dc.source | Journal of the Chilean Chemical Society v.55 n.4 2010 | |
| dc.subject | Benzodiazepines | |
| dc.subject | gas chromatography | |
| dc.subject | nitrogen-phosphorus detector | |
| dc.subject | micro-electron capture detector | |
| dc.title | DEVELOPMENT AND VALIDATION OF A GC-NPD/micro-ECD METHOD USING DUAL COLUMN FOR THE DETERMINATION OF BENZODIAZEPINE IN HUMAN WHOLE BLOOD AND PLASMA | |
| dc.type | Artículos de revistas | |
