In this study we have examinated the results of two experiments on the uptake and distribution of arsenic (As) in roots, shoots, and grain of wheat grown in As-polluted soils and in an unpolluted soil irrigated with As-contaminated water in absence or presence of phosphorus (P) fertilization. Arsenic concentrations in wheat samples of the two experiments are higher than those in the plants grown on uncontaminated soil. In the experiments showed in this work, it is highlighted the role of P fertilization in preventing As uptake and translocation in wheat plants. These findings could have important implications to reduce the potential risk posed to human health by As entering the food-chain.