Clinical impact of an angiotensin I-converting enzyme insertion/deletion and kinin B2 receptor +9/-9 polymorphisms in the prognosis of renal transplantation

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorHosp Israelita Albert Einstein
dc.creatorAmorim, Carlos E. N. [UNIFESP]
dc.creatorNogueira, Eliana [UNIFESP]
dc.creatorAlmeida, Sandro S. [UNIFESP]
dc.creatorGomes, Pedro P. G. [UNIFESP]
dc.creatorBacurau, Reury Frank Pereira
dc.creatorSuzete Ozaki, K. [UNIFESP]
dc.creatorCenedeze, Marcos A. [UNIFESP]
dc.creatorPacheco-Silva, Alvaro [UNIFESP]
dc.creatorCâmara, Niels Olsen Saraiva [UNIFESP]
dc.creatorAraujo, Ronaldo C. [UNIFESP]
dc.date.accessioned2016-01-24T14:31:23Z
dc.date.accessioned2022-10-07T21:29:23Z
dc.date.available2016-01-24T14:31:23Z
dc.date.available2022-10-07T21:29:23Z
dc.date.created2016-01-24T14:31:23Z
dc.date.issued2013-03-01
dc.identifierBiological Chemistry. Berlin: Walter de Gruyter & Co, v. 394, n. 3, p. 369-377, 2013.
dc.identifier1431-6730
dc.identifierhttp://repositorio.unifesp.br/handle/11600/36069
dc.identifier10.1515/hsz-2012-0314
dc.identifierWOS:000314757700008
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4029522
dc.description.abstractThere is a consensus in the scientific literature that supports the importance of the kallikrein kinin and renin angiotensin systems in renal physiology, but few studies have investigated their importance after renal transplantation. the aim of this study was to investigate the clinical effects of the insertion/deletion polymorphism in the angiotensin I-converting enzyme (ACE) gene and the +9/-9 polymorphism in the kinin B2 receptor (B2R) gene in kidney-transplanted patients (n=215 ACE, n=203 B2R) compared with 443 healthy individuals. Demographic results showed that there is a higher frequency of the D allele (high plasma ACE activity) and +9 allele (lower B2R expression) in transplant patients compared with control individuals. We also observed a higher frequency of these alleles in patients who had an elevated level of plasma creatinine. At day 7 post-transplantation, we found a higher prevalence of individuals with the DD genotype with elevated plasma creatinine level. Furthermore, individuals with the DD genotype had a higher chronic allograft dysfunction and graft loss compared with the II patient genotype, which showed no loss of graft. Taken together, our data suggest that the DD genotype is an indicator of an unfavorable prognosis following renal transplantation and could be related to kinin modulation.
dc.languageeng
dc.publisherWalter de Gruyter & Co
dc.relationBiological Chemistry
dc.rightsAcesso restrito
dc.subjectangiotensin I-converting enzyme (ACE)
dc.subjectB2 receptor
dc.subjectrenal transplantation
dc.titleClinical impact of an angiotensin I-converting enzyme insertion/deletion and kinin B2 receptor +9/-9 polymorphisms in the prognosis of renal transplantation
dc.typeArtigo


Este ítem pertenece a la siguiente institución