Artigo
Proteomic profile of seminal plasma in adolescents and adults with treated and untreated varicocele
Fecha
2016Registro en:
Asian Journal Of Andrology. Mumbai, v. 18, n. 2, p. 194-201, 2016.
1008-682X
WOS000370293900008.pdf
10.4103/1008-682X.168788
WOS:000370293900008
Autor
Camargo, Mariana [UNIFESP]
Intasqui, Paula [UNIFESP]
Bertolla, Ricardo Pimenta [UNIFESP]
Institución
Resumen
Varicocele, the most important treatable cause of male infertility, is present in 15% of adult males, 35% of men with primary infertility, and 80% of men with secondary infertility. On the other hand, 80% of these men will not present infertility. Therefore, there is a need to differentiate a varicocele that is exerting a deleterious effect that is treatable from a "silent" varicocele. Despite the growing evidence of the cellular effects of varicocele, its underlying molecular mechanisms are still eluding. Proteomics has become a promising area to determine the reproductive biology of semen as well as to improve diagnosis of male infertility. This review aims to discuss the state-of-art in seminal plasma proteomics in patients with varicocele to discuss the challenges in undertaking these studies, as well as the future outlook derived from the growing body of evidence on the seminal proteome.