Artigo
Acute cholestatic hepatitis caused by amoxicillin/clavulanate
Fecha
2013-12-14Registro en:
World Journal of Gastroenterology. Wanchai: Baishideng Publ Grp Co Ltd, v. 19, n. 46, p. 8789-8792, 2013.
1007-9327
10.3748/wjg.v19.i46.8789
WOS:000329129200039
Autor
Beraldo, Daniel Oliveira [UNIFESP]
Melo, Joanderson Fernandes
Bonfim, Alexandre Vidal [UNIFESP]
Teixeira, Andrei Alkmim [UNIFESP]
Teixeira, Ricardo Alkmim
Duarte, Andre Loyola
Institución
Resumen
Amoxicillin/clavulanate is a synthetic penicillin that is currently commonly used, especially for the treatment of respiratory and cutaneous infections. in general, it is a well-tolerated oral antibiotic. However, amoxicillin/clavulanate can cause adverse effects, mainly cutaneous, gastrointestinal, hepatic and hematologic, in some cases. Presented here is a case report of a 63-year-old male patient who developed cholestatic hepatitis after recent use of amoxicillin/clavulanate. After 6 wk of prolonged use of the drug, he began to show signs of cholestatic icterus and developed severe hyperbilirubinemia (total bilirubin > 300 mg/L). Diagnostic investigation was conducted by ultrasonography of the upper abdomen, serum tests for infection history, laboratory screening of autoimmune diseases, nuclear magnetic resonance (NMR) of the abdomen with bile duct-NMR and transcutaneous liver biopsy guided by ultrasound. the duration of disease was approximately 4 mo, with complete resolution of symptoms and laboratory changes at the end of that time period. Specific treatment was not instituted, only a combination of anti-emetic (metoclopramide) and cholestyramine for pruritus. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.