Artigo
Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization
Fecha
2008-07-01Registro en:
International Journal of Gynecology & Obstetrics. Clare: Elsevier B.V., v. 102, n. 1, p. 23-27, 2008.
0020-7292
10.1016/j.ijgo.2007.12.005
WOS:000257613500006
Autor
Serafini, Paulo
Rocha, Andre M.
Osorio, Cyntia T.
Silva, Ismael da [UNIFESP]
Motta, Eduardo L. [UNIFESP]
Baracat, Edmund C.
Institución
Resumen
Objective: To determine whether there is an association between endometrial expression of leukemia inhibitory factor (LIF) in the luteal phase of the menstrual cycle preceding in vitro fertilization (IVF) and treatment outcome. Methods: Biopsy specimens from the endometria of 52 women in the luteal. phase were immunostained against LIF Embryo culture and transfer were done according to standard procedures. Results: Clinical pregnancy occurred in 39% of the women following IVF, and strong endometrial immunohistochemical staining for LIF was associated with pregnancy (P=0.01). the women with a strong LIF expression had a 6.4-fold higher chance of becoming pregnant than those with weaker intensities (P=0.005). Conclusion: Endometrial expression of LIF during the luteal phase can be used as a predictor of IVF success. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.