Influence of chronic cocaine treatment and sleep deprivation on sexual behavior and neurogenesis of the male rat

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorAndersen, Monica Levy [UNIFESP]
dc.creatorPerry, Juliana Cini [UNIFESP]
dc.creatorBignotto, Magda [UNIFESP]
dc.creatorPerez-Mendes, Patricia [UNIFESP]
dc.creatorCinini, Simone Maria [UNIFESP]
dc.creatorMello, Luiz Eugenio Araujo de Moraes [UNIFESP]
dc.creatorTufik, Sergio [UNIFESP]
dc.date.accessioned2016-01-24T13:48:59Z
dc.date.accessioned2022-10-07T21:09:14Z
dc.date.available2016-01-24T13:48:59Z
dc.date.available2022-10-07T21:09:14Z
dc.date.created2016-01-24T13:48:59Z
dc.date.issued2007-08-15
dc.identifierProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 31, n. 6, p. 1224-1229, 2007.
dc.identifier0278-5846
dc.identifierhttps://repositorio.unifesp.br/handle/11600/29960
dc.identifier10.1016/j.pnpbp.2007.04.018
dc.identifierWOS:000249187300010
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4027112
dc.description.abstractThe present study investigated the influence of chronic cocaine treatment on genital reflexes associated with paradoxical sleep deprivation (PSD), and possible alterations in hippocampus neurogenesis of the male rat. At 21 days of age, the rats were distributed into two groups and injected with saline or cocaine (7 mg/kg, three times a week for 12 weeks). At age 90 days, they were submitted to a four-day period of PSD (PSD groups) or maintained in home-cages (control groups), challenged with saline or cocaine administration, and placed in observation cages to assess genital reflexes. Two additional groups were used to quantify neurogenesis. PSD rats treated chronically with cocaine and challenged with saline did not differ from their respective control groups. the association of PSD with cocaine potentiated penile erection (PE) when compared to PSD-saline (saline challenged) rats, and these effects were similar to those observed in long-term cocaine treated rats. the bromodeoxyuridine (BrdU) assay indicated a reduction in BrdU-positive cells in the adult hippocampus after chronic cocaine treatment. These findings show that long-term cocaine treatment from brain development through adulthood had a marked effect on sexual responses and neuronal proliferation. (C) 2007 Elsevier Inc. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationProgress in Neuro-psychopharmacology & Biological Psychiatry
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.rightsAcesso restrito
dc.subjectBrdU
dc.subjectCocaine
dc.subjectHippocampus
dc.subjectNeurogenesis
dc.subjectPenile erection
dc.subjectSleep deprivation
dc.titleInfluence of chronic cocaine treatment and sleep deprivation on sexual behavior and neurogenesis of the male rat
dc.typeResenha


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