Cardiovascular adjustments induced by hypertonic saline in hemorrhagic rats: Involvement of carotid body chemoreceptors

dc.contributorUniversidade Federal de Goiás (UFG)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorPedrino, Gustavo Rodrigues [UNIFESP]
dc.creatorRossi, Marcio Vinicius [UNIFESP]
dc.creatorSchoorlemmer, Gerhardus Hermanus Maria [UNIFESP]
dc.creatorLopes, Oswaldo Ubriaco [UNIFESP]
dc.creatorCravo, Sergio Luiz [UNIFESP]
dc.date.accessioned2016-01-24T14:06:12Z
dc.date.accessioned2022-10-07T21:02:05Z
dc.date.available2016-01-24T14:06:12Z
dc.date.available2022-10-07T21:02:05Z
dc.date.created2016-01-24T14:06:12Z
dc.date.issued2011-02-24
dc.identifierAutonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 160, n. 1-2, p. 37-41, 2011.
dc.identifier1566-0702
dc.identifierhttp://repositorio.unifesp.br/handle/11600/33474
dc.identifierWOS000287989000007.pdf
dc.identifier10.1016/j.autneu.2010.11.009
dc.identifierWOS:000287989000007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4026252
dc.description.abstractThe peripheral hyperosmolarity elicited by intravenous infusion of hypertonic saline brings potential benefits to the treatment of hemorrhage. the neural mechanisms involved in these beneficial effects remain unknown. the present study examines the role of carotid chemoreceptors in cardiovascular responses induced by hypertonic saline after hypovolemic hemorrhage in rats. Male Wistar rats (300-400 g) were anesthetized with thiopental, and instrumented for recording of mean arterial pressure. Arterial pressure was reduced to 60 mm Hg by withdrawal of arterial blood over 10 min, and maintained at this level for 60 min by withdrawal or infusion of blood. in control rats (n = 8) with intact chemoreceptors, the subsequent intravenous infusion of hypertonic saline (3M NaCl, 1.8 ml kg(-1) body weight, in 2 min) restored blood pressure (pressure increased from 61 +/- 4 to 118 +/- 5 mm Hg). in experimental rats (n = 8), the carotid body arteries were tied, 30 min after the beginning of the hypotensive phase, leaving the carotid chemoreceptors ischemic. in these rats, hypertonic saline failed to restore blood pressure (pressure increased from 55 +/- 1 to 70 +/- 6 mm Hg). These findings suggest that the restoration of blood pressure after hypovolemic hemorrhage induced by hypertonic saline depends on intact carotid chemoreceptors. (C) 2010 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationAutonomic Neuroscience-basic & Clinical
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.rightsAcesso aberto
dc.subjectCarotid body chemoreceptors
dc.subjectHypovolemic hemorrhage
dc.subjectHypertonic saline
dc.subjectArterial blood pressure and heart rate
dc.titleCardiovascular adjustments induced by hypertonic saline in hemorrhagic rats: Involvement of carotid body chemoreceptors
dc.typeArtigo


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