Artigo
Effect of fatty acid-rich diets on thymocyte proliferation and thymus involution during growing
Fecha
1993-03-01Registro en:
Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 53, n. 3, p. 531-534, 1993.
0031-9384
10.1016/0031-9384(93)90149-A
WOS:A1993KQ41100017
Autor
Egami, Mizue Imoto [UNIFESP]
Guimaraes, Augusto RP
Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
Curi, Rui
Institución
Resumen
The effect of polyunsaturated and saturated fatty acid-rich diet on the proliferation response of T and B lymphocytes in vitro was investigated. Also, a mitotic index of thymocytes and of thymus epithelial reticular-like cells and thymic involution coefficient were examined in vivo. w-6 PUFA-rich diet enhanced the rate of T (eightfold) and B (fourfold) lymphocyte proliferation, whereas saturated fatty acids did not show an important effect. However, both fat-rich diets increased the mitotic index of thymocytes and thymus involution index in vivo. These findings suggest that fat-rich diets may accelerate thymus involution during growing, possibly aggravating the impairment of the immune function which usually occurs under this condition.