Artigo
Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria
Fecha
2002-09-01Registro en:
Pharmaceutical Biology. Lisse: Swets Zeitlinger Publishers, v. 40, n. 6, p. 472-477, 2002.
1388-0209
10.1076/phbi.40.6.472.8436
WOS:000179940300014
Autor
Rodrigues, Marcelo Cairrão Araujo
Ribeiro, Alessandra Mussi
Pizzo, Andrea Baldocchi
Fontana, Andreia Cristina Karklin
Beleboni, Renê de Oliveira
Coutinho-Netto, Joaquim
Miranda, Antonio de [UNIFESP]
Santos, Wagner Ferreira dos
Institución
Resumen
In this article we describe an in vivo anticonvulsant effect from denatured crude venom and partially isolated fractions from two spiders: Parawixia bistriata and Scaptocosa raptoria. Intracerebroventricular injections of these venoms and fractions abolished rat convulsive tonic-clonic seizures induced by picrotoxin, bicuculline and pentylenetetrazole, and also, inhibited GABA uptake in synaptosomes of rat cerebral cortex. the venoms described in this work seems to be promising tools for the study of the GABAergic system, and may be a potential source for new anticonvulsant drugs.