Artigo
Sleep patterns over 15-day period in rats with spinal cord injury
Fecha
2007-05-01Registro en:
Spinal Cord. London: Nature Publishing Group, v. 45, n. 5, p. 360-366, 2007.
1362-4393
10.1038/sj.sc.3101971
WOS:000246307900005
Autor
Esteves, A. M.
Mello, Marco Tulio de [UNIFESP]
Squarcini, C. F. R.
Lancellotti, Carmen Lucia Penteado
Comparoni, Aniella [UNIFESP]
Tufik, Sergio [UNIFESP]
Institución
Resumen
Study design: Experimental, controlled trial.Objectives: the purpose of this study was to evaluate over a 15-day period alterations in sleep pattern of rats after spinal cord injury (SCI).Setting: Federal University of São Paulo, Department of Psychobiology.Methods: in total, 20 male Wistar rats were used. the rats were divided in two groups: SHAM and SCI. the rats were submitted to the following procedures: electrode insertion surgery, 24 h duration baseline sleep recording, SCI (level T9) and subsequent sleep recording for 15 consecutive days.Results: the results showed a reduction in sleep efficiency in the light period for Days 1-3, 5, 10 and 12 after SCI in relation to the SHAM group, with alterations in total waking time and sleep stages. Limb movements were observed 4 days after SCI.Conclusion: the present findings suggest that SCI may be heavily involved in altering sleep pattern in SCI subjects and that the inactivity caused by SCI may be exacerbating this altered sleep pattern.