Artigo
Reflex epileptic mechanisms in ictogenesis and therapeutic consequences
Fecha
2016Registro en:
Expert Review Of Neurotherapeutics. Abingdon, v. 16, n. 5, p. 573-585, 2016.
1473-7175
10.1586/14737175.2016.1169174
WOS:000374950900012
Autor
Lin, Katia
Guaranha, Mirian [UNIFESP]
Wolf, Peter
Institución
Resumen
Recent studies of reflex epileptic mechanisms in human epilepsy using advanced methods of neurophysiology and functional neuroimaging have contributed much to elucidate pathophysiological processes of seizure generation. Whereas in lesional focal epilepsies reflex mechanisms usually relate directly to the anatomical focus, in system epilepsies they have helped to define which functional anatomical systems serving physiological function are recruited by the ictogenic mechanisms. Reflex epileptic seizures can often be prevented by avoidance or modification of triggers or by prophylactic benzodiazepine administration. Surgical options apply to focal cases. According to restricted experiences with pharmacotherapy, without controlled studies and little information on new AEDs, reflex seizures in system epilepsies appear to respond best to valproic acid and in focal epilepsies, to carbamazepine.