| dc.creator | Golalipour,Mohammad Jafar | |
| dc.creator | Ghafari,Soraya | |
| dc.creator | Kouri,Vahid | |
| dc.creator | Kestkar,Abbas Ali | |
| dc.date | 2010-06-01 | |
| dc.date.accessioned | 2017-03-07T16:27:46Z | |
| dc.date.available | 2017-03-07T16:27:46Z | |
| dc.identifier | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200011 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/401998 | |
| dc.description | This investigation was carried out to evaluate the effect of the extract of Urtica dioica leaves on hyperglycemia and quantitative changes of b-cells in streptozotocin-diabetic rats. Forty male Wistar rats were allocated in groups of normal, diabetic, treatment and protective. Hyperglycemia induced by administrating one dose of 80 mg/kg streptozotocin (STZ) intraperitoneally. Animals in treatment group received Urtica dioica (100 mg/kg/day) for 4 weeks intraperitoneally, one week after injection of STZ. In protective group animals received U. dioica (100 mg/kg/day) for 5 days before inducing diabetes. After five weeks the animals were sacrificed and whole pancreas removed. Pancreas specimens were used for quantitative morphometric analysis after Chromealum hematoxiline - phloxine staining. The mean ± SE of b-cells in non hyperglycemic animals in protective group was higher than in hyperglycemic animals in the same group (54.33 ± 2.4 versus 1.25 ± 0.5, P<0.05). Hyperglycemia was improved in 6 (60%) of rats in protective group and 1 (10%) rat in treatment group OR=0.07 (CI 95%: 0.0-1.1, p=0.06). The logistic regression analysis showed an association between decrease of blood glucose, increase of number of b-cells and administration of Urtica before induction of diabetes. This study showed proliferation of b-cells when of the U. dioica leaves extract (100 mg/kg/day) administrated before induction of diabetes in animal model. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad Chilena de Anatomía | |
| dc.source | International Journal of Morphology v.28 n.2 2010 | |
| dc.subject | Streptozotocin | |
| dc.subject | Diabetes | |
| dc.subject | Urtica dioica | |
| dc.subject | Rat | |
| dc.subject | Pancreas | |
| dc.subject | b-cells | |
| dc.subject | Blood glucose | |
| dc.title | Proliferation of the b -Cells of Pancreas in Diabetic Rats Treated with Urtica Dioica | |
| dc.type | Artículos de revistas | |
