Artigo
Effects of the selective M1 muscarinic receptor antagonist dicyclomine on emotional memory
Fecha
2000-09-01Registro en:
Learning & Memory. Plainview: Cold Spring Harbor Lab Press, v. 7, n. 5, p. 287-292, 2000.
1072-0502
WOS000168802100007.pdf
10.1101/lm.34900
WOS:000168802100007
Autor
Fornari, Raquel V. [UNIFESP]
Moreira, Karin M. [UNIFESP]
Oliveira, Maria Gabriela M [UNIFESP]
Institución
Resumen
The nonselective muscarinic antagonist scopolamine is known to impair the acquisition of some learning tasks such as inhibitor) avoidance. There has been recent research into the effects of this drug in contextual fear conditioning and tone fear conditioning paradigms. the purpose of the present study was to assess the role of the selective M1 muscarinic antagonist dicyclomine in these paradigms and in the inhibitory avoidance test. Rats were administered different doses of dicyclomine or saline 30 min before acquisition training. the animals were tested 24 hr later, and it was observed that 16 mg/kg of dicyclomine impaired both contextual fear conditioning and inhibitor) avoidance. However, dicyclomine (up to 64 mg/kg) did not affect tone fear conditioning. These results suggest that the selective M1 muscarinic antagonist dicyclomine differentially affects aversively motivated tasks known to be dependent on hippocampal integrity (such as contextual fear conditioning and inhibitory avoidance) but does not affect similar hippocampus-independent tasks.