SODIUM DICLOFENAC INHIBITS HYPERTHERMIA-INDUCED BY PARADOXICAL SLEEP-DEPRIVATION - the POSSIBLE PARTICIPATION of PROSTAGLANDINS

Abstract

Sodium diclofenac inhibits hyperthermia induced by paradoxical sleep deprivation (PSD), which suggests the participation of prostaglandins. the temperature of paradoxical sleep-deprived rats increased from the first to the fourth day of deprivation. This hyperthermia was blocked on the second, third, and fourth days by daily administration, twice a day, of 10 mg/kg of sodium diclofenac, a potent prostaglandin synthesis inhibitor. in the dose of 10 mg/kg, a decrease of temperature was observed only on the second and third days of PSD. These data suggest the participation of prostaglandins in modulating the increase in temperature during PSD.