Artigo
The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin
Fecha
2004-01-01Registro en:
Peptides. New York: Elsevier B.V., v. 25, n. 1, p. 81-89, 2004.
0196-9781
10.1016/j.peptides.2003.12.008
WOS:000220267900011
Autor
Dale, C. S.
Goncalves, LRC
Juliano, L.
Juliano, M. A.
Silva, AMM da
Giorgi, R.
Institución
Resumen
The effect of a synthetic peptide (H-92-G(110)) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p. (C) 2004 Elsevier Inc. All rights reserved.