A simple reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of rosiglitazone (RGL) and gliclazide (GLC) in puré and pharmaceutical dosage forms. Aphenomenex Gemini reverse phase C column (150x4.6mm i.d., 5µ) was used with a mobile phase containing a mixture of acetonitrile and water (pH 3 adjusted with ortho phosphoric acid) in the ratio of 70: 30. The flow rate was 0.6mL/min. and effluents were monitored at 250nm and eluted at 2.41min. (RGL) and 5.22min. (GLC). Calibration curve was plotted with a range from 0.025-2.5µg/mL for RGL and 0.08 to 8µg/mL for GLC. The assay was validated for the parameters like accuracy (>97.87% recovery), precision (intra-day and inter-day with %RSD < 2), robustness and system suitability parameters. Henee the method was found to suitable for the routine quality control of the drugs in puré and pharmaceutical dosage forms.