ESR, ELECTROCHEMICAL AND ORAC STUDIES OF NITRO COMPOUNDS WITH POTENTIAL ANTIPROTOZOAL ACTVITY

dc.creatorARAVENA C,MARÍA
dc.creatorFIGUEROA,ROBERTO
dc.creatorOLEA-AZAR,CLAUDIO
dc.creatorARÁN,VICENTE J
dc.date2010-06-01
dc.date.accessioned2017-03-07T16:26:02Z
dc.date.available2017-03-07T16:26:02Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200022
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/401543
dc.descriptionCyclic Voltammetry (CV) and electrón spin resonance (ESR) techniques were used in the investigation of several potentially antiprotozoal nitro derivatives of dihydroquinoxaline and indazole. A self-protonation process involving protonation of the nitro group due to the presence of an acidic protón in the structure of the nitro compound was observed in the first step of an ECErev reduction mechanism. ESR spectra of the free radicals obtained by electrochemical reduction in situ were characterized and analyzed. The ESR spectra showed three different hyperfine patterns for both families of compounds. In order to evaluate the free radical scavenger properties of these nitrocompounds we carried out ORAC-Fl (Oxygen Radical Antioxidant Capacity) assay. These derivatives showed a low antioxidant capacity.
dc.formattext/html
dc.languageen
dc.publisherSociedad Chilena de Química
dc.sourceJournal of the Chilean Chemical Society v.55 n.2 2010
dc.subjectESR
dc.subjectChagas' disease
dc.subjectORAC
dc.subjectCyclic Voltammetry
dc.subjectNitro compounds
dc.titleESR, ELECTROCHEMICAL AND ORAC STUDIES OF NITRO COMPOUNDS WITH POTENTIAL ANTIPROTOZOAL ACTVITY
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución