dc.creatorKrepsky, Patricia Baier
dc.creatorIsidório, Raquel Geralda
dc.creatorSouza Filho, José Dias de
dc.creatorCôrtes, Steyner França
dc.creatorBraga, Fernão Castro
dc.creatorKrepsky, Patricia Baier
dc.creatorIsidório, Raquel Geralda
dc.creatorSouza Filho, José Dias de
dc.creatorCôrtes, Steyner França
dc.creatorBraga, Fernão Castro
dc.date.accessioned2022-10-07T19:37:45Z
dc.date.available2022-10-07T19:37:45Z
dc.date.issued2012
dc.identifier0944-7113
dc.identifierhttp://repositorio.ufba.br/ri/handle/ri/15242
dc.identifierv. 19, n. 11
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4014041
dc.description.abstractThe aerial parts of Cuphea carthagenensis (Jacq.) J.F. Macbride (Lythraceae) are traditionally employed in Brazil to treat cardiovascular diseases. The aim of this study was to compare preparations of C. carthagenensis aerial parts (aqueous and ethanol extracts, together with derived fractions) with regard to their total phenolic contents and in vitro vasodilating activity. The main flavonoids found in the extracts were isolated and identified as quercetin derivatives. The extracts and fractions showed similar HPLC profiles with the presence of quercetin-5-O-β-glucopyranoside, quercetin-3-O-α-arabinofuranoside and quercetin-3-sulfate in all of them, but marked differences in the contents of flavonoids, proanthocyanidins, tannis and total phenolics. Excepting the aqueous extract, all assayed preparations elicited vasodilatation on pre-contracted rat aortic rings in the range of pIC50 4.53 ± 0.03 to 4.98 ± 0.06. Polynomial regression analysis demonstrated the relationship between vasodilating activity and the contents of flavonoids (r2 = 0.5190), proanthocyanidins (r2 = 0.8016), tannins (r2 = 0.8041) and total phenolics (r2 = 0.6226), suggesting the participation of these compounds in the pharmacological effect and their potential use as chemical markers for the species.
dc.languageen
dc.rightsAcesso Aberto
dc.sourcehttp://dx.doi.org/ 10.1016/j.phymed.2012.05.011
dc.subjectCuphea carthagenensis
dc.subjectTotal phenolic contents
dc.subjectQuercetin5-O-β-glucopyranoside
dc.subjectQuercetin-3-O-α-arabinofuranoside
dc.subjectVasodilator effect
dc.titleChemical composition and vasodilatation induced by Cuphea carthagenensis preparations
dc.typeArtigo de Periódico


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