Artigo de Periódico
The fragility of protein-protein interaction networks
Fecha
2011Registro en:
0295-5075
v. 95, n. 1
Autor
Andrade, Roberto Fernandes Silva
Schneider, C. M.
Shinbrot, T.
Herrmann, H. J.
Andrade, Roberto Fernandes Silva
Schneider, C. M.
Shinbrot, T.
Herrmann, H. J.
Institución
Resumen
The capacity to resist perturbations from the environment is crucial to the survival of all organisms. We quantitatively analyze the susceptibility of protein interaction networks of numerous organisms to random and targeted failures. We find for all organisms studied that random rewiring improves protein network robustness, so that actual networks are more fragile than rewired surrogates. This unexpected fragility contrasts with the behavior of networks such as the Internet, whose robustness decreases with random rewiring. We trace this surprising effect to the modular structure of protein networks.