Artigo de Periódico
Clinical manifestations associated with HTLV type I infection: a cross-sectional study
Fecha
2007Registro en:
0889-2229
v. 23, n. 3
Autor
Caskey, Marina F.
Morgan, Daniel J.
Porto, Maria Aurélia da Fonseca
Giozza, Silvana P.
Muniz, André Luís Nunes
Orge, Glória O.
Travassos, Maria J.
Barrón, Yolanda
Carvalho Filho, Edgar Marcelino de
Glesby, Marshall J.
Caskey, Marina F.
Morgan, Daniel J.
Porto, Maria Aurélia da Fonseca
Giozza, Silvana P.
Muniz, André Luís Nunes
Orge, Glória O.
Travassos, Maria J.
Barrón, Yolanda
Carvalho Filho, Edgar Marcelino de
Glesby, Marshall J.
Institución
Resumen
Human T-lymphotropic virus type I (HTLV-I) causes HTLV-I-associated myelopathy/tropical spastic paraparesis and adult T cell leukemia in a small percentage of infected individuals. HTLV-I infection is increasingly associated with clinical manifestations. To determine the prevalence of clinical manifestations in HTLV-I infected individuals, we conducted a cross-sectional study of 115 HTLV-I-infected blood donors without myelopathy and 115 age- and sex-matched seronegative controls. Subjects answered a standardized questionnaire and underwent physical examination. Compared with controls, HTLV-I-infected subjects were more likely to report arm or leg weakness (OR = 3.8, 95% CI: 1.4–10.2; OR = 4.0, 95% CI: 1.6–9.8, respectively), hand or foot numbness (OR = 2.1, 95% CI: 1.1–3.9; OR = 4.8, 95% CI: 2.0–11.7, respectively), arthralgia (OR = 3.3, 95% CI: 1.7–6.4), nocturia (OR = 2.7, 95% CI: 1.04–6.8), erectile dysfunction (OR = 4.0, 95% CI: 1.6–9.8), and to have gingivitis (OR = 3.8, 95% CI: 1.8–7.9), periodontitis (OR = 10.0, 95% CI: 2.3–42.8), and dry oral mucosa (OR = 7.5, 95% CI: 1.7–32.8). HTLV-I infection is associated with a variety of clinical manifestations, which may occur in patients who have not developed myelopathy.