Artigo de Periódico
Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
Fecha
2011Registro en:
1043-4666
v. 56, n. 2
Autor
Goncalves, Marilda S.
Cerqueira, Bruno A. V.
Vilas Boas, Wendell
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
Goncalves, Marilda S.
Cerqueira, Bruno A. V.
Vilas Boas, Wendell
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
Institución
Resumen
Sickle cell anemia (SCA) is a common, severe monogenetic disorder characterized by chronic hemolysis, frequent infections, a chronic inflammatory state and recurrent occlusions of the microcirculation, resulting in painful crises, organ damage and premature death. This study evaluated associations between serum levels of IL-18, uric acid, hemolytic markers, and inflammatory molecules in SCA patients. A cross-sectional study was performed including 45 SCA patients (median age of 20.5 years) without general symptoms and who had not undergone blood transfusions. Inclusion criteria for the steady-state SCA patients were the absence of hospitalization and the absence of infections. Interleukin-18 and uric acid levels were correlated closely with markers of hemolysis, endothelial dysfunction and others cytokines levels. These findings suggest probable influences of IL-18 and uric acid in the pathophysiology of vascular occlusion in SCA. Additional studies should be performed to characterize similar prognosis markers and possible therapeutic targets.