Artigo de Periódico
Antimicrobial activity and structural study of disubstituted Thiourea Derivatives
Fecha
2007Registro en:
0026-9247
v. 138, n. 5
Autor
Cunha, Silvio do Desterro
Macedo Junior, Fernando César de
Costa, Giselle A. Nobre
Rodrigues Junior, Manoel T.
Verde, Rosival B. V.
Souza Neta, Lourdes Cardoso de
Vencato, Ivo
Lariucci, Carlito
Sá, Fernando P.
Cunha, Silvio do Desterro
Macedo Junior, Fernando César de
Costa, Giselle A. Nobre
Rodrigues Junior, Manoel T.
Verde, Rosival B. V.
Souza Neta, Lourdes Cardoso de
Vencato, Ivo
Lariucci, Carlito
Sá, Fernando P.
Institución
Resumen
The antimicrobial activity of six N-phenyl- and fourteen N-benzoylthiourea derivatives were evaluated from their Minimal Inhibitory Concentration (MIC) values using the microdilution procedure against ten microorganisms. Most of the compounds exhibited selective activity against fungi and Gram-positive bacteria, which were very effectively inhibited by some of the tested thioureas. Additionally, SAR considerations and four novel X-ray diffraction structures of N-benzoylthioureas are included.