Brasil
| Artigo de Periódico
Photochemical and pharmacological aspects of nitric oxide release from some nitrosyl ruthenium complexes entrapped in sol–gel and silicone matrices
Fecha
2007Registro en:
0277-5387
v. 26, n. 16
Autor
Lima, Renata Galvão de
Sauaia, Marilia Gama
Ferezin, Camila
Pepe, Iuri Muniz
José, Nadia Mamede
Bendhack, Lusiane Maria
Rocha, Zênis Novais da
Silva, Roberto Santana da
Lima, Renata Galvão de
Sauaia, Marilia Gama
Ferezin, Camila
Pepe, Iuri Muniz
José, Nadia Mamede
Bendhack, Lusiane Maria
Rocha, Zênis Novais da
Silva, Roberto Santana da
Institución
Resumen
The entrapped [Ru(terpy)(L)NO](PF6)3, where terpy = 2,2′:6′,2″-terpyridine and L = 2,2′-bipyridine (bpy) and 3,4-diiminebenzoic acid (NH · NHq) complexes into sol–gel processed polysiloxane and silicone matrices, shows NO release characteristics when submitted to light irradiation at 355 and 532 nm, as judged by NO measurement using a NO-sensor electrode. The pharmacological properties of doped matrix showed vasodilator characteristics by visible light irradiation, which is of great interest because the target delivery system can avoid the occurrence of side effects possibly by the aquo ruthenium species. All matrices obtained showed to be amorphous materials. The scanning electron micrographs of the matrices showed irregularly shaped particles, with a broad size of 1000 μm for both matrices and homogeneous distribution.