Artigo de Periódico
Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala
Fecha
2009Registro en:
0032-0943
v. 75, n. 4
Autor
Lima, Murilo M. C.
López, Jorge A.
David, Jorge Mauricio
Silva, Eliezer P.
Giulietti, Ana M.
Queiroz, Luciano Paganucci de
David, Juceni Pereira de Lima
Lima, Murilo M. C.
López, Jorge A.
David, Jorge Mauricio
Silva, Eliezer P.
Giulietti, Ana M.
Queiroz, Luciano Paganucci de
David, Juceni Pereira de Lima
Institución
Resumen
Chemical investigation of the leaves of Waltheria brachypetala Turks (Sterculiaceae) resulted in the isolation of quinolinone alkaloids, waltherione-A, waltherione-B (N-methylwaltherione-A), 8-methoxyflindersine, and the cyclic peptide alkaloid waltherine. The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Waltherione-A, waltherione-B and waltherine showed significant activity.