Artigo de Periódico
Serum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemia
Fecha
2013Registro en:
0003-9969
v. 58, n. 5
Autor
Veiga, Patricia C.
Schroth, Robert J.
Guedes, Rosalina
Freire, Songeli Meneses
Nogueira Filho, Getúlio da Rocha
Veiga, Patricia C.
Schroth, Robert J.
Guedes, Rosalina
Freire, Songeli Meneses
Nogueira Filho, Getúlio da Rocha
Institución
Resumen
Objective: The aim of this study was to evaluate possible immunologic relationships between
sickle cell anaemia (SCA) and periodontal inflammation and its impact on serum
cytokines.
Design: Twenty-five Brazilian children of African descent were involved in this study and
divided in two groups: SCA (n = 10): confirmed diagnosis of homozygous anaemia; and
CTR-control (n = 15): no sickle anaemia. Clinical examination included comprehensive
medical (routine physical evaluation) and periodontal exams: plaque index (PI), bleeding
on probing (BoP), and haematological analysis. Serum samples were collected for cytokine
evaluation by microarray. Clinical and laboratorial parameters were compared statistically
(alpha = 5%).
Results: The higher values of PI and BoP were similar for both groups ( p > 0.05) confirming a
diagnosis of generalized gingivitis for all individuals. Intergroup analysis showed higher
levels of interferon gamma (IFNg), tumour necrosis alpha (TNFa), interleukin (IL)-4, -5, -8, -10
and 13 only in the SCA group ( p < 0.05). In addition, PI was negatively correlated with IL-2,
IL-4, IL-5, IL-6, IL-8 and IL-13, while BoP was positively correlated with IL-10.
Conclusion: Within the limits of the present study, it was concluded that SCA increase the
levels of serum cytokines regardless of the presence of periodontal inflammation. Therefore,
a direct immunological relationship between SCA and periodontal inflammation was
not established.