Leishmania mexicana: Immunology and histopathology in C3H mice
dc.creator | Grimaldi Jr., Gabriel | |
dc.creator | Moriearty, Pamela Lane | |
dc.creator | Grimaldi Jr., Gabriel | |
dc.creator | Moriearty, Pamela Lane | |
dc.date.accessioned | 2013-02-28T16:42:29Z | |
dc.date.accessioned | 2022-10-07T16:23:39Z | |
dc.date.available | 2013-02-28T16:42:29Z | |
dc.date.available | 2022-10-07T16:23:39Z | |
dc.date.created | 2013-02-28T16:42:29Z | |
dc.date.issued | 1980 | |
dc.identifier | 0014-4894 | |
dc.identifier | http://www.repositorio.ufba.br/ri/handle/ri/8717 | |
dc.identifier | v. 50, n. 1 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/4007307 | |
dc.description.abstract | Leishmania mexicana: Immunology and histopathology in C3H mice. Experimental Parasitology 50, 45-56. C3H mice were infected subcutaneously with lo5 promastigotes of Leishmania mexicana and subsequent lesions were examined at 3, 5, and 8 months. All animals developed persistent nonulcerating nodules of variable size which did not metastasize. The nodules contained amastigotes with a mononuclear infiltrate of histiocytes, lymphocytes, and plasma cells, but without formation of tuberculoid-type granulomas. Neutrophils and eosinophils were also encountered in some cases. Specific antileishmanial antibodies and delayed-type hypersensitivity to leishmanial antigen were present at 3, 5, and 8 months postinfection. L. mexicana infection in C3H mice differs from classic self-healing cutaneous leishmaniasis by the persistence of nonhealing, nonulcerating, nonmetastasizing lesions, despite evidence of cellular and humoral immunity. | |
dc.language | en | |
dc.publisher | Experimental Parasitology | |
dc.source | http://dx.doi.org/10.1016/0014-4894(80)90006-5 | |
dc.subject | Leishmania mexicana | |
dc.subject | Protozoa | |
dc.subject | parasitic | |
dc.subject | Hemoflagellate | |
dc.subject | Mice | |
dc.subject | C3H | |
dc.subject | Leishmaniasis | |
dc.subject | cutaneous | |
dc.subject | Immunofluorescence | |
dc.subject | Indirect hemagglutination | |
dc.subject | Delayed hypersensitivity | |
dc.subject | Ear thickness test | |
dc.subject | Histopathology | |
dc.title | Leishmania mexicana: Immunology and histopathology in C3H mice | |
dc.type | Artigo de Periódico |