Artigo de Periódico
Leishmania mexicana: Immunology and histopathology in C3H mice
Fecha
1980Registro en:
0014-4894
v. 50, n. 1
Autor
Grimaldi Jr., Gabriel
Moriearty, Pamela Lane
Grimaldi Jr., Gabriel
Moriearty, Pamela Lane
Institución
Resumen
Leishmania mexicana: Immunology
and histopathology in C3H mice. Experimental Parasitology 50, 45-56. C3H
mice were infected subcutaneously with lo5 promastigotes of Leishmania mexicana and
subsequent lesions were examined at 3, 5, and 8 months. All animals developed persistent
nonulcerating nodules of variable size which did not metastasize. The nodules contained
amastigotes with a mononuclear infiltrate of histiocytes, lymphocytes, and plasma cells, but
without formation of tuberculoid-type granulomas. Neutrophils and eosinophils were also
encountered in some cases. Specific antileishmanial antibodies and delayed-type hypersensitivity
to leishmanial antigen were present at 3, 5, and 8 months postinfection. L. mexicana
infection in C3H mice differs from classic self-healing cutaneous leishmaniasis by the persistence
of nonhealing, nonulcerating, nonmetastasizing lesions, despite evidence of cellular
and humoral immunity.