Brasil
| Artigo de Periódico
The first bismuth(III)-catalyzed guanylation of thioureas
Fecha
2006Registro en:
0040-4039
v.47, n.39
Autor
Cunha, Silvio do Desterro
Rodrigues Jr., Manoel T.
Cunha, Silvio do Desterro
Rodrigues Jr., Manoel T.
Institución
Resumen
This work describes the first catalytic bismuth-promoted synthesis of polysubstituted guanidines in good yields through the guanylation reaction of N-benzoyl or N-phenylthioureas with primary and secondary amines, but now employing equimolar amounts of each organic reagent. Both bismuth iodine and bismuth nitrate were efficient as inorganic thiophiles at only 5 mol % in relation to substrates, being the first example of inorganic thiophiles acting in guanylation at catalytic levels