Artigo de Periódico
Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
Fecha
2011-02Registro en:
0909-8836
v. 119, n. 1
Autor
Planello, Aline C.
Campos, Maria Isabela Guimarães
Meloto, Carolina B.
Secolin, Rodrigo
Rizatti-Barbosa, Célia M.
Line, Sergio R. P.
Souza, Ana P. de
Planello, Aline C.
Campos, Maria Isabela Guimarães
Meloto, Carolina B.
Secolin, Rodrigo
Rizatti-Barbosa, Célia M.
Line, Sergio R. P.
Souza, Ana P. de
Institución
Resumen
Temporomandibular joint (TMJ) degeneration is a frequent cause of orofacial pain.
Matrix metalloproteinases (MMPs) degrade extracellular matrix components and play
an important role in TMJ degeneration. We investigated the frequency of the MMP1
1G/2G polymorphism (rs1799750), the MMP3 5A/6A polymorphism (rs3025058), and
the MMP9 C/T polymorphism (rs3918242) in individuals with TMJ degeneration, in
order to analyze the association of polymorphisms in these genes with TMJ degeneration.
The population studied comprised 117 healthy controls and 115 individuals
diagnosed with TMJ degeneration upon examination of magnetic resonance imaging
(MRI) and computed tomography (CT) images. Genotypes were determined using
PCR restriction fragment length polymorphism (RFLP). Logistic regression analyses
revealed an association between the MMP1 2G/2G genotype and degeneration; in
contrast, there was no association between either the MMP3 or the MMP9 genotype
and degeneration. Our results may indicate a role for the MMP1 polymorphism in
TMJ degeneration.