Artigo de Periódico
IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection
Fecha
2011Registro en:
0141-9838
v. 33, n. 2
Autor
Novoa, R.
Bacellar, Maria Olívia Amado Ramos
Nascimento, M.
Cardoso, T. M.
Ramasawmy, Rajendranath
Oliveira, W. N.
Schriefer, Nicolaus Albert Borges
Carvalho Filho, Edgar Marcelino de
Novoa, R.
Bacellar, Maria Olívia Amado Ramos
Nascimento, M.
Cardoso, T. M.
Ramasawmy, Rajendranath
Oliveira, W. N.
Schriefer, Nicolaus Albert Borges
Carvalho Filho, Edgar Marcelino de
Institución
Resumen
Cutaneous leishmaniasis (CL) is characterized by high
production of pro-inflammatory cytokines and development of pathology. Individuals with subclinical L. braziliensis infection (SC) have a positive skin test to leishmania, but
do not develop disease. We evaluated whether the downregulation of inflammatory response in SC is mediated by IL-10 and IL-27 and whether IL-17 is associated with control of
infection. Participants include SC individuals, patients with CL and healthy subjects. Cytokines protein and mRNA were
detected by ELISA and real-time PCR. IFN-c and TNF-a levels were higher in CL than in SC group. The IL-10 levels and mRNA for IL-10 were similar in both SC and CL.
mRNA for IL-27 was increased in cells from SC after stimulation with L. braziliensis antigen. There was a tendency for increased levels of IL-17 in SC compared to CL. The
weak type 1 immune response observed in SC L. braziliensis infection is not because of the regulatory effects of IL-10 and IL-27. The control of Leishmania infection may be
mediated by innate immune response with participation of IL-17. The results from this pilot study warrant further larger studies to investigate the potential contributions of IL-17 and IL-27 to the control of L. braziliensis infection