Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains

dc.creatorRuiz, Jerônimo Conceição
dc.creatorFerreira, Vívian D'Afonseca da Silva
dc.creatorSilva, Artur Luiz da Costa da
dc.creatorAli, Amjad
dc.creatorPinto, Anne Cybelle
dc.creatorSantos, Anderson Rodrigues dos
dc.creatorRocha, Aryane Aparecida Magalhães Cassiano
dc.creatorLopes, Débora de Oliveira
dc.creatorDorella, Fernanda Alves
dc.creatorPacheco, Luis Gustavo Carvalho
dc.creatorCosta, Marcilia Pinheiro da
dc.creatorTurk, Meritxell Zurita
dc.creatorSeyffert, Núbia
dc.creatorMoraes, Pablo Matias Ribeiro de Oliveira
dc.creatorSoares, Siomar de Castro
dc.creatorAlmeida, Sintia Silva de
dc.creatorCastro, Thiago Luiz de Paula
dc.creatorAbreu, Vinicius Augusto Carvalho de
dc.creatorTrost, Eva
dc.creatorBaumbach, Jan
dc.creatorTauch, Andreas
dc.creatorSchneider, Maria Paula Cruz
dc.creatorMcCulloch, John Anthony
dc.creatorCerdeira, Louise Teixeira
dc.creatorRamos, Rommel Thiago Juca
dc.creatorZerlotini, Adhemar
dc.creatorDominitini, Anderson
dc.creatorResende, Daniela de Melo
dc.creatorCoser, Elisângela Monteiro
dc.creatorOliveira, Luciana Márcia de
dc.creatorPedrosa, André Luiz
dc.creatorUeira-Vieira, Carlos
dc.creatorGuimarães, Claudia Teixeira
dc.creatorBartholomeu, Daniela C.
dc.creatorOliveira, Magalhães de
dc.creatorSantos, Fabrício R.
dc.creatorRabelo, Élida Mara
dc.creatorLobo, Francisco Pereira
dc.creatorFranco, Gloria Regina
dc.creatorCosta, Ana Flávia
dc.creatorCastro, Ieso M.
dc.creatorDias, Sílvia Regina Costa
dc.creatorFerro, Jesus Aparecido
dc.creatorOrtega, José Miguel
dc.creatorPaiva, Luciano Vilela
dc.creatorGoulart Filho, Luiz Ricardo
dc.creatorAlmeida, Juliana Franco
dc.creatorFerro, Maria Inês Tiraboschi
dc.creatorCarneiro, Newton Portilho
dc.creatorFalcão, Paula Regina Kuser
dc.creatorGrynberg, Priscila
dc.creatorTeixeira, Santuza Maria Ribeiro
dc.creatorBrommonschenkel, Sérgio
dc.creatorOliveira, Sérgio Costa
dc.creatorNascimento, Roberto José Meyer
dc.creatorMoore, Robert J.
dc.creatorMiyoshi, Anderson
dc.creatorOliveira, Guilherme C.
dc.creatorAzevedo, Vasco Ariston de Carvalho
dc.creatorRuiz, Jerônimo Conceição
dc.creatorFerreira, Vívian D'Afonseca da Silva
dc.creatorSilva, Artur Luiz da Costa da
dc.creatorAli, Amjad
dc.creatorPinto, Anne Cybelle
dc.creatorSantos, Anderson Rodrigues dos
dc.creatorRocha, Aryane Aparecida Magalhães Cassiano
dc.creatorLopes, Débora de Oliveira
dc.creatorDorella, Fernanda Alves
dc.creatorPacheco, Luis Gustavo Carvalho
dc.creatorCosta, Marcilia Pinheiro da
dc.creatorTurk, Meritxell Zurita
dc.creatorSeyffert, Núbia
dc.creatorMoraes, Pablo Matias Ribeiro de Oliveira
dc.creatorSoares, Siomar de Castro
dc.creatorAlmeida, Sintia Silva de
dc.creatorCastro, Thiago Luiz de Paula
dc.creatorAbreu, Vinicius Augusto Carvalho de
dc.creatorTrost, Eva
dc.creatorBaumbach, Jan
dc.creatorTauch, Andreas
dc.creatorSchneider, Maria Paula Cruz
dc.creatorMcCulloch, John Anthony
dc.creatorCerdeira, Louise Teixeira
dc.creatorRamos, Rommel Thiago Juca
dc.creatorZerlotini, Adhemar
dc.creatorDominitini, Anderson
dc.creatorResende, Daniela de Melo
dc.creatorCoser, Elisângela Monteiro
dc.creatorOliveira, Luciana Márcia de
dc.creatorPedrosa, André Luiz
dc.creatorUeira-Vieira, Carlos
dc.creatorGuimarães, Claudia Teixeira
dc.creatorBartholomeu, Daniela C.
dc.creatorOliveira, Magalhães de
dc.creatorSantos, Fabrício R.
dc.creatorRabelo, Élida Mara
dc.creatorLobo, Francisco Pereira
dc.creatorFranco, Gloria Regina
dc.creatorCosta, Ana Flávia
dc.creatorCastro, Ieso M.
dc.creatorDias, Sílvia Regina Costa
dc.creatorFerro, Jesus Aparecido
dc.creatorOrtega, José Miguel
dc.creatorPaiva, Luciano Vilela
dc.creatorGoulart Filho, Luiz Ricardo
dc.creatorAlmeida, Juliana Franco
dc.creatorFerro, Maria Inês Tiraboschi
dc.creatorCarneiro, Newton Portilho
dc.creatorFalcão, Paula Regina Kuser
dc.creatorGrynberg, Priscila
dc.creatorTeixeira, Santuza Maria Ribeiro
dc.creatorBrommonschenkel, Sérgio
dc.creatorOliveira, Sérgio Costa
dc.creatorNascimento, Roberto José Meyer
dc.creatorMoore, Robert J.
dc.creatorMiyoshi, Anderson
dc.creatorOliveira, Guilherme C.
dc.creatorAzevedo, Vasco Ariston de Carvalho
dc.date.accessioned2012-02-27T13:03:23Z
dc.date.accessioned2022-10-07T15:11:13Z
dc.date.available2012-02-27T13:03:23Z
dc.date.available2022-10-07T15:11:13Z
dc.date.created2012-02-27T13:03:23Z
dc.date.issued2011
dc.identifier1932-6203
dc.identifierhttp://www.repositorio.ufba.br/ri/handle/ri/5467
dc.identifierv. 6, n. 4.
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4004476
dc.description.abstractBackground: Corynebacterium pseudotuberculosis, a Gram-positive, facultative intracellular pathogen, is the etiologic agent of the disease known as caseous lymphadenitis (CL). CL mainly affects small ruminants, such as goats and sheep; it also causes infections in humans, though rarely. This species is distributed worldwide, but it has the most serious economic impact in Oceania, Africa and South America. Although C. pseudotuberculosis causes major health and productivity problems for livestock, little is known about the molecular basis of its pathogenicity. Methodology and Findings: We characterized two C. pseudotuberculosis genomes (Cp1002, isolated from goats; and CpC231, isolated from sheep). Analysis of the predicted genomes showed high similarity in genomic architecture, gene content and genetic order. When C. pseudotuberculosis was compared with other Corynebacterium species, it became evident that this pathogenic species has lost numerous genes, resulting in one of the smallest genomes in the genus. Other differences that could be part of the adaptation to pathogenicity include a lower GC content, of about 52%, and a reduced gene repertoire. The C. pseudotuberculosis genome also includes seven putative pathogenicity islands, which contain several classical virulence factors, including genes for fimbrial subunits, adhesion factors, iron uptake and secreted toxins. Additionally, all of the virulence factors in the islands have characteristics that indicate horizontal transfer. Conclusions: These particular genome characteristics of C. pseudotuberculosis, as well as its acquired virulence factors in pathogenicity islands, provide evidence of its lifestyle and of the pathogenicity pathways used by this pathogen in the infection process. All genomes cited in this study are available in the NCBI Genbank database (http://www.ncbi.nlm.nih.gov/ genbank/) under accession numbers CP001809 and CP001829.
dc.languageen
dc.sourceDOI: 10.1371/journal.pone.0018551
dc.titleEvidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains
dc.typeArtigo de Periódico


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