Artigo de Periódico
Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice.
Fecha
2007Registro en:
09712119
v. 7, n. 2
Autor
Silva, Alessandra E.
Ferreira, Enio
Ocarino, Natália de Melo
Moraes, Jader R. C.
Cassali, Geovanni Dantas
Serakides, Rogéria
Silva, Alessandra E.
Ferreira, Enio
Ocarino, Natália de Melo
Moraes, Jader R. C.
Cassali, Geovanni Dantas
Serakides, Rogéria
Institución
Resumen
The effect of hypothyroidism on the
ascitic form of Ehrlich tumor in either
non-ovariectomized or ovariectomized
adult female mice was studied.
Hypothyroidism was induced by
treatment with propylthiouracil (PTU).
Forty mice were divided into four
groups: ovariectomized hypothyroid,
non-ovariectomized hypothyroid,
ovariectomized euthyroid, and nonovariectomized
euthyroid. Mice were
inoculated intraperitoneally with a suspension
of 29 x 106 cells and tumor growth curve was determined by measuring
abdominal circumference for 10
days. At the end of the experimental
period, mice were sacrificed.
Hypothyroidism resulted in lower
abdominal circumference and lower volume
of ascitic liquid. However, hypothyroidism
did not affect the viability or
concentration of tumor cells, the nucleus-
cytoplasm ratio, or the mean nuclear
diameter of neoplastic cells.The number
of nucleolar organizer regions (NOR) of
neoplastic cells did not differ among
groups.
In conclusion, hypothyroidism,
regardless of the functional state of the
gonads, resulted in a delayed growth of
the ascitic form of Ehrlich tumor as it
reduced the liquid volume and did not
reduce the number, viability, or diameter
of neoplastic cells.