Artigo Publicado em Periódico
Model of induction of thyroid dysfunctions in adult female mice
Fecha
2007-10Registro en:
0102-0935
v. 59, n. 5
Autor
Ferreira, E.
Lima, Alessandra Estrela da Silva
Serakides, R.
Gomes, A. S.
Cassali, Geovanni Dantas
Ferreira, E.
Lima, Alessandra Estrela da Silva
Serakides, R.
Gomes, A. S.
Cassali, Geovanni Dantas
Institución
Resumen
It is described the elaboration of a protocol to induce hyperthyroidism and hypothyroidism in mice by
administrating thyroxin and propylthiouracil, respectively, in the drinking water. The drugs were
administered to adult female mice of the Swiss strain for 30 days in order to obtain a systemic status of
thyroid dysfunction. The induction of hyperthyroidism and hypothyroidism in the animals was confirmed
by the histomorphological analysis of the thyroid in the end of the experiment, when the state of gland
dysfunction in the animals submitted to the treatment was observed.