Artículos de revistas
Origin and Development of the Coronary Arteries
Autor
Silva-Junior,Geraldo de Oliveira
Miranda,Sandro Wilson da Silva
Mandarim-de-Lacerda,Carlos Alberto
Institución
Resumen
The formation of the coronary vasculature is a fundamental event in heart development and involves a series of carefully regulated temporal events that include vasculogenesis and angiogenesis. This review focuses the knowledge concerning the formation of the coronary arteries available so far and some molecular mechanisms involved in this process. Understanding coronary embryogenesis is important for interventions regarding adult cardiovascular diseases as well as those necessary to correct heart congenital defects. The insight of the coronary artery development as a result of ingrowth changed the understanding of several congenital coronary artery variations and anomalies described in gross anatomy.