Artículos de revistas
SIMULTANEOUS QUANTITATION OF OLMESARTAN MEDOXOMIL AND AMLODIPINE BESYLATE IN COMBINED TABLETS USING HPLC
Autor
QUTAB,SYED SHANAZ
RAZZAQ,SYED NAEEM
ASHFAQ,MUHAMMAD
KHAN,ISLAM ULLAH
MUMTAZ,AHMAD MAHMOOD
Institución
Resumen
A simple, sensitive and isocratic reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of olmesartan medoxomil and amlodipine in pharmaceutical tablet formulations. HPLC analysis was carried out using reverse phase isocratic elution with aC18 column and amobilephase of 0.05 Mammonium acetate pH 6.8 and acetonitrile intheratio of 40:60, v/v. Detection of the analytes was achieved using UV detector at 239 nm. The retention times of olmesartan medoxomil and amlodipine were 2.50 and 3.94 respectively Linearity of the method was found to be in the concentration range of 16-112 µgml-1 for olmesartan medoximil and 4-28 µgml-1 for amlodipine. The correlation coefficient value was greaterthan 0.9999 for both the analytes. The method is suitable for the estimation of both the components simultaneously in pharmaceutical tablet formulations.