masterThesis
Estudo da caracterização imunofenotípica de pacientes idosos com leucemia mielóide aguda no Rio Grande do Norte
Fecha
2016-10-31Registro en:
FERNANDES, Leonardo de Lima. Estudo da caracterização imunofenotípica de pacientes idosos com leucemia mielóide aguda no Rio Grande do Norte. 2016. 83f. Dissertação (Mestrado em Ciências Farmacêuticas) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2016.
Autor
Fernandes, Leonardo de Lima
Resumen
Acute Myeloid Leukemia (AML) is the most frequent leukemia in adult over 60 years
of age in more than 50% of the cases represented 15 to 20% of childhood leukemias
and 80% of adult leukemias, with a poor prognosis, especially in elderly patients. The
Myelodysplastic Syndromes (MDS) comprise another spectrum of acute clonal
cancers that also involve mainly older age group of individuals and are characterized
by ineffective hematopoiesis, peripheral cytopenia, chromosomal abnormalities and a
variable predilection of progression to AML. Elderly patients with Acute Myeloid
Leukemia (AML) is part of a biological and clinically distinct group having a
decreased response to chemotherapy. This study aimed to carry out an investigative
study of Acute Myeloid Leukemias in a group of elderly patients at the diagnosis, to
determine the clinical and biological characteristics of these leukemias. The data
analysis showed that 56 patients had newly diagnosed AML (70%) 6 with recurrent
disease (7.5%), 15 had transformed MDS (18.7%) and refractory AML 3 (3.7%).
About clinical aspects, there was a predominance of splenomegaly (91.2%), followed
by hepatomegaly (76.2%). Laboratory findings showed predominance of
hyperleukocytosis (91.3%), thrombocytopenia (85%) and anemia (86.2%). Most
cases had FAB classification M1 (36.6%), M2 (17.5%) and M4 (23.7%). Our Data
analysis was statistically significant (p <0.05) and showed correlation of CD7 (25%),
PgP (45%), p53 (30%) and Bcl-2 (30%) with increasing disease status, likely
contributing to a worse prognosis in this group of patients. Our results demonstrate
the importance of clinical and laboratory investigation of these groups of patients in
order to obtain more information about these cancers. This work was submitted to
the ethics committee of the University Hospital Onofre Lopes and obtained approval
under number 359/09.