masterThesis
Avaliação da atividade anti-inflamatória de géis a base de extratos vegetais de plantas do nordeste brasileiro: Jatropha gossypiifolia e Ipomoea pes-caprae
Fecha
2018-12-19Registro en:
SANTOS, Jacinthia Beatriz Xavier dos. Avaliação da atividade anti-inflamatória de géis a base de extratos vegetais de plantas do nordeste brasileiro: Jatropha gossypiifolia e Ipomoea pes-caprae. 2018. 103f. Dissertação (Mestrado em Ciências Farmacêuticas) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2018.
Autor
Santos, Jacinthia Beatriz Xavier dos
Resumen
The inflammatory process is a physiological event, whose events
generated in this process are caused by the release of inflammatory mediators,
aiming to restore homeostasis. Anti-inflammatory drugs are used for the treatment
of inflammations, however, prolonged therapy leads to the appearance of adverse
reactions that may be harmful to the patient, and the search for new, safer and
more effective alternatives becomes relevant. In this context, medicinal plants,
such as the plant species Jatropha gossypiifolia (Jg) and Ipomoea pes-caprae
(Ipc) can be highlighted as strong candidates, since in traditional medicine they
are popularly used for a wide range of curative purposes, including inflammatory
conditions. In this sense, in the present study the obtain of gels containing the
vegetal extracts of these species and the evaluation of their topical antiinflammatory activity were carried out, using the models of ear edema induced by
single application of crton oil and paw edema induced by carrageenan (acute
inflammation) and ear edema induced by multiple application of chrotonic oil
(chronic inflammation). The gels presented adequate physico-chemical
characteristics and were stable during 30 days of observation, showing no change
in color, odor or appearance. The gels had pH similar to the cutaneous pH, thus
minimizing the appearance of irritation or cutaneous alteration, results that
corroborated with the in vivo skin irritation test, where the gels showed no clinical
signs of toxicity between the 14 days of observation, indicating product safety
developed for topical use. Jg gels demonstrated significant acute antiinflammatory activity in ear edema, and this activity was significantly increased
when equivalent amounts of the extract were applied incorporated into the
developed gels, and also reduced the levels of edema, nitrite and MPO enzyme in
the gels. ears of mice, with intensity similar to dexamethasone (anti-inflammatory
pattern). The Ipc extract showed no activity in the acute ear edema model, even
after gel incorporation, however, it significantly inhibited paw edema throughout
the duration of the dexamethasone-like experiment. Gels of 1.0% and Ipc 5% also
showed a significant anti-inflammatory effect in the chronic inflammation test,
reducing edema (also observed in the histopathological analysis) and oxidative
(lipid peroxidation and reduced glutathione depletion) dexamethasone. Thus, this
study demonstrated the anti-inflammatory potential of the gels with the extracts of
the species J. gossypiifolia and I. pes-caprae, and can serve as starting point for
the development of herbal products for the treatment of inflammatory processes.